中央大学 小松研究室(生命分子化学)

研究業績Publications

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論文誌の表紙を飾った最近の研究成果

原著論文・総説(2000~2009)

The Role of an Amino Acid Triad at the Entrance of the Heme Pocket in Human Serum Albumin for O2 and CO Binding to Iron Protoporphyrin IX
T. Komatsu, A. Nakagawa, S. Curry, E. Tsuchida, K. Murata, N. Nakamura, H. Ohno
Org. Biomol. Chem. 2009, 7, 3836−3841. Abstract

Structural and Mutagenic Approach to Create Human Serum Albumin-Based Oxygen Carrier and Photosensitizer (Review Article)
T. Komatsu, A. Nakagawa, X. Qu
Drug Metab. Pharmacokinet. 2009, 24, 287−299. Abstract

O2 Binding Properties of Human Serum Albumin Quadruple Mutants Complexed Iron Protoporphyrin IX with Axial His-186 Coordination
A. Nakagawa, T. Komatsu, S. Curry, E. Tsuchida
Chem. Lett. 2009, 38, 776−777. Abstract

Artificial Oxygen Carriers, Hemoglobin Vesicles and Albumin-Hemes Based on Bioconjugate Chemistry (Review Article)
E. Tsuchida, K. Sou, A. Nakagawa, H. Sakai, T. Komatsu, K. Kobayashi
Bioconjugate Chem. 2009, 20, 1419−1440. Abstract
 ・Front Cover 

Functional Evaluation of Iron Oxypyriporphyrin in Protein Heme Pocket
S. Neya, M. Suzuki, H. Ode, T. Hoshino, Y. Furutani, H. Kandori, H. Hori, K. Imai, T. Komatsu
Inorg. Chem. 2008, 47, 10771−10778. Abstract

Protein Nanotubes Comprised of an Alternate Layer-by-Layer Assembly using a Polycation as an Electrostatic Glue
X. Qu, G. Lu, E. Tsuchida, T. Komatsu
Chem. Eur. J. 2008, 14, 10303−10308. Abstract

Human Serum Albumin Nanotubes Comprising Layer-by-Layer Assembly with Polycation
G. Lu, E. Tsuchida, T. Komatsu
Chem. Lett. 2008, 37, 972−973. Abstract

Structure, Photophysical Property, and Cytotoxicity of Human Serum Albumin Complexed with Tris(dicarboxymethylene)[60]fullerene
X. Qu, T. Komatsu, T. Sato, O. Glatter, H. Horinouchi, K. Kobayashi, E. Tsuchida
Bioconjugate Chem. 2008, 19, 1556−1560. Abstract

Enhanced Radiation Response of a Solid Tumor with the Artificial Oxygen Carrier 'Albumin-Heme'
H. Horinouchi, H. Yamamoto, T. Komatsu, Y. Huang, E. Tsuchida, K. Kobayashi
Cancer Sci. 2008, 99, 1274−1278. Abstract

O2 Binding to Human Serum Albumin Incorporating Iron Porphyrin with a Covalently Linked Methyl-L-Histidine Isomer
A. Nakagawa, T. Komatsu, M. Iizuka, E. Tsuchida
Bioconjugate Chem. 2008, 19, 581−584. Abstract

Genetic Engineering of the Heme Pocket in Human Serum Albumin: Modulation of O2 Binding of Iron Protoporphyrin IX by Variation of Distal Amino Acids
T. Komatsu, A. Nakagawa, P. A. Zunszain, S. Curry, E. Tsuchida
J. Am. Chem. Soc. 2007, 129, 11286−11295. Abstract

O2-Binding Albumin Thin Films: Solid Membranes of Poly(ethylene glycol)-Conjugated Human Serum Albumin Incorporating Iron Porphyrin
A. Nakagawa, T. Komatsu, Y. Huang, G. Lu, E. Tsuchida
Bioconjugate Chem. 2007, 18, 1673−1677. Abstract

Artificial Hemoprotein Nanotubes
G. Lu, T. Komatsu, E. Tsuchida
Chem. Commun. 2007, 2980−2982. Abstract
 ・Highlighted by Chemical Science

Influence of O2-Carrying Plasma Hemoprotein "Albumin-Heme" on Complement System and Platelet Activation in vitro and Physiological Responses to Exchange Transfusion
T. Komatsu, Y. Huang, S. Wakamoto, H. Abe, M. Fujihara, H. Azuma, H. Ikeda, H. Yamamoto, H. Horinouchi, K. Kobayashi, E. Tsuchida
J. Biomed. Mater. Res. 2007, 81A, 821−826. Abstract

Induced Long-Range Attractive Potentials of Human Serum Albumin by Ligand Binding
T. Sato, T. Komatsu, A. Nakagawa, E. Tsuchida
Phys. Rev. Lett. 2007, 98, 208101-1−4. Abstract

meso-Tetrakis(α,α,α,α-o-amidophenyl)porphinatoiron(II) Bearing a Proximal Histidyl Group at the β-pyrrolic Position via an Acyl Bond: Synthesis and O2 Coordination in Aqueous Media
A. Nakagawa, T. Komatsu, E. Tsuchida
Chem. Lett. 2007, 36, 640−641. Abstract

Photosensitized Reduction of Water to Hydrogen using Human Serum Albumin Complexed with Zinc Protoporphyrin IX
T. Komatsu, R.-M. Wang, P. A. Zunszain, S. Curry, E. Tsuchida
J. Am. Chem. Soc. 2006, 128, 16297−16301. Abstract
 ・Highlighted by Chemistry World

PEGylated Albumin-Heme as an Oxygen-Carrying Plasma Expander: Exchange Transfusion into Acute Anemia Rat Model
Y. Huang, T. Komatsu, H. Yamamoto, H. Horinouchi, K. Kobayashi, E. Tsuchida
Biomaterials 2006, 27, 4477−4483. Abstract

Poly(ethylene glycol)-Conjugated Human Serum Albumin Including Iron Porphyrins: Surface Modification Improves the O2-Transporting Ability
Y. Huang, T. Komatsu, R.-M. Wang, A. Nakagawa, E. Tsuchida
Bioconjugate Chem. 2006, 17, 393−398. Abstract

Human Serum Albumin Hybrid Incorporating Tailed Porphyrinatoiron(II) in the α,α,α,β-Conformer as an O2-Binding Site
A. Nakagawa, T. Komatsu, M. Iizuka, E. Tsuchida
Bioconjugate Chem. 2006, 17, 146−151. Abstract

Albumin Clusters: Structurally Defined Protein Tetramer and Oxygen Carrier Including Thirty-Two Iron(II) Porphyrins
T. Komatsu, Y. Oguro, A. Nakagawa, E. Tsuchida
Biomacromolecules 2005, 6, 3397−3403. Abstract

O2 and CO Binding Properties of Artificial Hemoproteins Formed by Complexing Iron Protoporphyrin IX with Human Serum Albumin Mutants
T. Komatsu, N. Ohmichi, A. Nakagawa, P. A. Zunszain, S. Curry, E. Tsuchida
J. Am. Chem. Soc. 2005, 127, 15933−15942. Abstract
 ・Highlighted by Chemistry World

Heat-Resistant Oxygen-Carrying Hemoproteins Consist of Recombinant Xylanases and Synthetic Iron(II) Porphyrin
T. Komatsu, S. Ishihara, E. Tsuchida, H. Nishide, C. Inokuma, S. Nakamura
Biomacromolecules 2005, 6, 1489−1494. Abstract

Human Serum Albumin Bearing Covalently Attached Iron(II) Porphyrins as O2-Coodination Sites
R.-M. Wang, T. Komatsu, A. Nakagawa, E. Tsuchida
Bioconjugate Chem. 2005, 16, 23−26. Abstract

Exchange Transfusion with Synthetic Oxygen-Carrying Plasma Protein "Albumin-Heme" into an Acute Anemia Rat Model after Seventy-Percent Hemodilution
T. Komatsu, H. Yamamoto, Y. Huang, H. Horinouchi, K. Kobayashi, E. Tsuchida
J. Biomed. Mater. Res. 2004, 71A, 644−651. Abstract

Physicochemical Characterization of Cross-Linked Human Serum Albumin Dimer and Its Synthetic Heme Hybrid as an Oxygen Carrier
T. Komatsu, Y. Oguro, Y. Teramura, S. Takeoka, J. Okai, M. Anraku, M. Otagiri, E. Tsuchida
Biochim. Biophys. Acta 2004, 1675, 21−31. Abstract

Dioxygenation of Human Serum Albumin Having a Prosthetic Heme Group in a Tailor-Made Heme Pocket
T. Komatsu, N. Ohmichi, P. A. Zunszain, S. Curry, E. Tsuchida
J. Am. Chem. Soc. 2004, 126, 14304−14305. Abstract

Synthesis of Protoheme IX Derivatives with a Covalently Linked Proximal-Base and Their Human Serum Albumin Hybrids as Artificial Hemoprotein
A. Nakagawa, N. Ohmichi, T. Komatsu, E. Tsuchida
Org. Biomol. Chem. 2004, 2, 3108−3112. Abstract

Exchange Transfusion with Entirely Synthetic Red-Cell Substitute Albumin-Heme into Rats: Physiological Responses and Blood Biochemical Tests
Y. Huang, T. Komatsu, H. Yamamoto, H. Horinouchi, K. Kobayashi, E. Tsuchida
J. Biomed. Mater. Res. 2004, 71A, 63−69. Abstract

Molecular Energy and Electron Transfer Assemblies Made of Self-Organized Lipid-Porphyrin Bilayer Vesicles
T. Komatsu, M. Moritake, E. Tsuchida
Chem. Eur. J. 2003, 9, 4626−4633. Abstract

Crystal Structural Analysis of Human Serum Albumin Complexed with Hemin and Fatty Acid
P. A. Zunszain, J. Ghuman, T. Komatsu, E. Tsuchida, S. Curry
BMC Struct. Biol. 2003, 3, 6. Abstract

Synthetic Dioxygen-Carrying Hemoprotein. Human Serum Albumin Including Iron(II) Complex of Protoporphyrin IX with an Axially Coordinated Histidylglycyl-Propionate
A. Nakagawa, T. Komatsu, N. Ohmichi, E. Tsuchida
Chem. Lett. 2003, 32, 504−505. Abstract

Human Serum Albumin Incorporating Synthetic Heme: Red Blood Cell Substitute without Hypertension by Nitric Oxide Scavenging
E. Tsuchida, T. Komatsu, Y. Matsukawa, A. Nakagawa, H. Sakai, K. Kobayashi, M. Suematsu
J. Biomed. Mater. Res. 2003, 64A, 257−261. Abstract

Oxygenation of Hypoxic Region in Solid Tumor by Administration of Human Serum Albumin Incorporating Synthetic Hemes
K. Kobayashi, T. Komatsu, A. Iwamaru, Y. Matsukawa, M. Watanabe, H. Horinouchi, E. Tsuchida
J. Biomed. Mater. Res. 2003, 64A, 48−51. Abstract

Thermostable Synthetic Hemoproteins: Thermophilic Xylanases Hybridized with Dioxygen- Carrying meso-Tetrakis(o-pivalamidophenyl)porphinatoiron(II) Derivative
T. Komatsu, S. Ishihara, H. Nishide, E. Tsuchida, C. Morokuma, S. Nakamura
Chem. Lett. 2003, 32, 108−109. Abstract

meso-Tetrakis[o-(N-methyl)pyridinium]porphyrin Ensembles with Axially Coordinated Cyclodextrin-Penetrating Phenethylimidazole: Reversible Dioxygen-Binding in Aqueous DMF Solution
T. Komatsu, S. Hayakawa, E. Tsuchida, H. Nishide
Chem. Commun. 2003, 50−51. Abstract

Oxygenation of Hypoxic Region in Solid Tumor by Administration of Human Serum Albumin Incorporating Synthetic Hemes
K. Kobayashi, T. Komatsu, A. Iwamaru, Y. Matsukawa, M. Watanabe, H. Horinouchi, E. Tsuchida
J. Biomed. Mater. Res. 2003, 64A, 48−51. Abstract

Self-Organized Lipid-Porphyrin Bilayer Membranes in Vesicular Form: Nanostructure, Photophysical Properties, and Dioxygen Coordination
T. Komatsu, M. Moritake, A. Nakagawa, E. Tsuchida
Chem. Eur. J. 2002, 8, 5469−5480. Abstract

Preservation Stability and In Vivo Administration of Albumin-Heme Hybrid Solution as an Entirely Synthetic O2-Carrier
E. Tsuchida, T. Komatsu, T. Yanagimoto, H. Sakai
Polym. Adv. Technol. 2002, 13, 845−850. Abstract

Effect of Heme Structure on O2-Binding Properties of Human Serum Albumin-Heme Hybrids: IntramolecularHistidine Coordination Provides a Stable O2-Adduct Complex
T. Komatsu, Y. Matsukawa, E. Tsuchida
Bioconjugate Chem. 2002, 13, 397−402. Abstract

Photoreduction of a Self-Assembled (Lipidporphyrinato)iron(III) Complex in Saline by LMCT Excitation: Co-Aggregated Hyaluronic Acid Allows an Irreversible Electron Transfer
T. Yanagimoto, A. Nakagawa, T. Komatsu, E. Tsuchida
Bull. Chem. Soc. Jpn. 2001, 74, 2123−2128. Abstract

Electrochemical Studies of Albumin-Heme Hybrid in Aqueous Media by Modified Electrode
Y Wu, T. Komatsu, E. Tsuchida
Inorg. Chim. Acta 2001, 322, 120−124.

Iron(II) Complex of Octopus-Porphyrin with a Covalently Linked Proximal Imidazole; Self-Assembly and O2-Coordination in Aqueous Media
T. Komatsu, S. Hayakawa, T. Yanagimoto, M. Kobayakawa, A. Nakagawa, E. Tsuchida
Bull. Chem. Soc. Jpn. 2001, 74, 1703−1707. Abstract

O2-Binding Properties of Double-Sided Porphinatoiron(II)s with Polar Substituents and Their Human Serum Albumin Hybrids
T. Komatsu, T. Okada, M. Moritake, E. Tsuchida
Bull. Chem. Soc. Jpn. 2001, 74, 1695−1702. Abstract

O2-Adduct Complex of meso-Tetrakis(α,α,α,α-o-pivalamidophenyl)porphinatoiron(II) with an Intramolecularly Coordinated Proximal Histidine
T. Komatsu, Y. Matsukawa, K. Miyatake, E. Tsuchida
Chem. Lett. 2001, 30, 668−669. Abstract

Photoreduction of Autooxidized Albumin-Heme Hybrid in Saline Solution: Revival of Its O2-Binding Ability
A. Nakagawa, T. Komatsu, E. Tsuchida
Bioconjugate Chem. 2001, 12, 648−652. Abstract

Reaction of Nitric Oxide with Synthetic Hemoprotein, Human Serum Albumin Incorporating Tetraphenylporphinatoiron(II) Derivatives
T. Komatsu, Y. Matsukawa, E. Tsuchida
Bioconjugate Chem. 2001, 12, 71−75. Abstract

Kinetics of CO and O2 Binding to Human Serum Albumin-Heme Hybrid
T. Komatsu, Y. Matsukawa, E. Tsuchida
Bioconjugate Chem. 2000, 11, 772−776. Abstract

Redox Behavior of Human Serum Albumin-Heme Hybrid on Graphite Electrode Modified with Didodecyldimethylammonium Bromide
Y. Wu, T. Komatsu, E. Tsuchida
Chem. Lett. 2000, 29, 1194−1195. Abstract

Nitrosyl Iron(II) Copmlex of meso-Tetrakis(α,α,α,α-o-pivalamidophenyl)porphyrin with a Covalently Linked 2-Methylimidazolylalkyl Group
T. Komatsu, Y. Matsukawa, E. Tsuchida
Chem. Lett. 2000, 29, 1060−1061. Abstract

Photoinduced Electron Transfer between Lipidporphyrinato-Zinc(II) and -Iron(III) Complexes in Phospholipid Vesicular Membrane
T. Yanagimoto, T. Komatsu, E. Tsuchida
Inorg. Chim. Acta 2000, 305, 26−31.

Photoreduction of Self-Assembled Lipidporphyrinatoiron(III) Chloride with Hyaluronic Acid under Semi-Physiological Conditions
T. Komatsu, T. Yanagimoto, A. Nakagawa, E. Tsuchida
Chem. Lett. 2000, 29, 84−85. Abstract

Exchange Transfusion of Albumin-Heme as an Artificial O2-Infusion into Anesthetized Rats: Physiological Responses, O2-Delivery and Reduction of the Oxidized Hemin Sites by Red Blood Cells
E. Tsuchida, T. Komatsu, K. Hamamatsu, Y. Matsukawa, A. Tajima, A. Yoshizu, Y. Izumi, K. Kobayashi
Bioconjugate Chem. 2000, 11, 46−50. Abstract


2000年以前の論文・総説は省略