Komatsu Lab Chuo University

Protein Micro/NanotubesProtein Mikro/Nanoröhren


The attraction of the cylindrical hollow (tubular) structure is to provide different functions to the inner pore space, tube wall, and outer surface, independently. We have synthesized protein nanotubes by a unique alternate layer-by-layer assembly technique in a porous polycarbonate membrane. Hepatitis B virus, influenza virus, E. coli, and doxorubicin-loaded liposomes are efficiently incorporated into the inner space of the tube. Placing the enzyme in the innermost layer causes the hydrolysis reaction of the substrate and ring-opening polymerization of the lactone. In addition to proteins and water-soluble polymers, DNA and gold nanoparticles (AnNP) can be used as constituents of the tube wall.

Chem. Asian J. 2021
Chem. Lett. 2020 "Highlight Review"
Chem. Commun. 2020
Chem. Asian J. 2018
Chem. Commun. 2014 "Cover Image" "Highlighted by Chemistry World"
Langmuir 2013
Nanoscale 2012 "Review"
J. Am. Chem. Soc. 2011 "Highlighted by Chemistry World"
ACS Nano 2010
ACS Nano 2010 "Highlighted by Nanowerk"

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