We have found that protein microtubes with platinum nanoparticles (PtNP) or catalase on the inner wall are self-propelled by jeting oxygen bubbles from the open-end terminus in water. The tubes with iron oxide as the layer component can be guided using a magnet. In the case of the catalase tube motor, the enzyme activity changes depending on the pH and temperature, it is therefore posible to control the velocity. By modifying the outer surface, the tubes function as a micro carrier that captures and transports the desired substance or bacteria, and a catalyst that has a self-stirring ability. Microtube motors consisting of only proteins are highly biodegradable and are expected to be applied in the medical and diagnostic fields.