Komatsu Lab Chuo University

PublicationsPublikationen

写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます 写真の説明を入れます
Recent results adopted on journal cover images

Original Papers (2010−)

Protein-Based Smart Microtubes and Nanotubes as Ultrasmall Biomaterials [Highlight Review]
T. Komatsu
Chem. Lett. 2020, 49, in press. AbstractNEW

Haemoglobin(βK120C)-Albumin Trimer as Artificial O2 Carrier with Sufficiernt Haemoglobin Allostery
Y. Morita, A. Saito, J. Yamaguchi, T. Komatsu
RSC Chem. Biol. 2020, 1, 128−136. AbstractNEW
 ・Cover Image 

Lewis Acid–Base Synergistic Catalysis of Cationic Halogen-Bonding-Donors with Nucleophilic Counter Anions
K. Torita, R. Haraguchi, Y. Morita, S. Kemmochi, T. Komatsu, S. Fukuzawa
Chem. Commun. 2020, 56, in press. AbstractNEW

Rectangular Holes in Porphyrin Isomers Act as Mono- and Bi-Nucleating Ligands: Stereochemistry of Mono- and Di-Boron Porphycenes and Their Protonation Behaviors
N. Xu, T. Ono, Y. Morita, T. Komatsu, Y. Hisaeda
Inorg. Chem. 2020, 59, in press.NEW

Neuroprotective Effects of Combination Therapy of Regional Cold Perfusion and Hemoglobin-Based Oxygen Carrier Administration on Rat Transient Cerebral Ischemia
Y. Ito, T. Abumiya, T. Komatsu, R. Funaki, M. Gekka, K. Kurisu, T. Sugiyama, M. Kawabori, T. Osanai, N. Nakayama, K. Kazumata, K. Houkin
Brain Res. 2020, 1746, 147012:1‒8. AbstractNEW

Liophilized Hemoglobin-Albumin Cluster with Disaccharides: Long-Term Storable Powder of Artificial O2 Carrier
R. Funaki, H. Iwasaki, T. Kashima, T. Komatsu
Polym. Adv. Technol. 2020, 31, 1122−1126. Abstract

Development of Canine and Feline Serum Albumins and Their Applications for Artificial Red Blood Cells [Review in Japanese]
T. Komatsu, T. Hasegawa, Y. Morita
MVM (J. Modern Vet. Med.), 2020, 189, 102−107. Content

Genetically Engineered Haemoglobin Wrapped Covalently with Human Serum Albumins as an Artificial O2 Carrier
R. Funaki, W. Okamoto, C. Endo, Y. Morita, K. Kihira, T. Komatsu
J. Mater. Chem. B 2020, 8, 1139−1145. Abstract
 ・Cover Image 

Protein Nanoparticles Formed by Self-Assembly of Human Serum Albumin with a Fatty Acid Arm
Y. Morita, D. Takahashi, T. Komatsu
Chem. Lett. 2020, 49,103−106. Abstract
 ・Selected as an "Editor's Choice"
 ・Open Access Article
 ・Inside Cover 

Nonbubble-Propelled Biodegradable Microtube Motors Consisting Only of Protein
N. Sugai, Y. Morita, T. Komatsu
Chem. Asian J. 2019, 14, 2953−2957. Abstract
 ・Selected as a "Very Important Paper" (VIP)

Protein Microtube Motors with a Pt Nanoparticle Interior and Avidin Exterior for Self-Propelled Transportation, Separation, and Stirring
Y. Nakai, N. Sugai, H. Kusano, Y. Morita, T. Komatsu
ACS Appl. Nano Mater. 2019, 2, 4891−4899. Abstract
 ・Cover Image 

Hemoglobin(βC93A)-Albumin Cluster: Mutation of Cysteine-β93 to Alanine Allows Moderate Reduction of O2 Affinity by Inositol Hexaphosphate
Y. Morita, K. Igarashi, R. Funaki, T. Komatsu
ChemBioChem 2019, 20, 1684−1687. Abstract

Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin
K. Sakurama, K. Nishi, S. Imoto, M. Hashimoto, T. Komatsu, Y. Morita, K. Taguchi, M. Otagiri, K. Yamasaki
J. Pharm. Sci. 2019, 108, 1890−1895. Abstract

Microtube Motors Self-Propelled by Enzyme Reaction Aiming at Applications in Biomedical Field [in Japanese]
T. Komatsu, N. Sugai
Chemistry「化学」, 2019, 74, 66−67.

Hemoglobin-Albumin Clusters Prepared using N-Succinimidyl 3-Maleimidopropionate as an Appropriate Crosslinker
R. Funaki, T. Kashima, W. Okamoto, S. Sakata, Y. Morita, M. Sakata, T. Komatsu
ACS Omega 2019, 4, 3228−3233. Abstract
 ・Open Access Article

Physicochemical Properties and Crystal Structures of Recombinant Canine and Feline Serum Albumins [Review]
T. Komatsu, K. Kihira, K. Yamada, K. Yokomaku, M. Akiyama, Y. Morita
Int. J. Microgravity Sci. Appl. 2019, 36, 360104:1−6. Abstract

Hemoglobin-Albumin Cluster: Physiological Responses after Exchange Transfusion into Rats and Blood Circulation Persistence in Dogs
H. Iwasaki, K. Yokomaku, M. Kureishi, K. Igarashi, R. Hashimoto, M. Kohno, M. Iwazaki, R. Haruki, M. Akiyama, K. Asai, Y. Nakamura, R. Funaki, Y. Morita, T. Komatsu
Artif. Cells Nanomed. Biotechnol. 2018, 46, S621−S629. Abstract

Quaternary Structure Analysis of a Hemoglobin Core in Hemoglobin-Albumin Cluster
Y. Morita, T. Yamada, M. Kureishi, K. Kihira, T. Komatsu
J. Phys. Chem. B 2018, 122, 12031−12039. Abstract

Stratiform Protein Microtube Reactors Containing Glucose Oxidase Layer
R. Adachi, M. Akiyama, Y. Morita, T. Komatsu
Chem. Asian J. 2018, 13, 2796−2799. Abstract

Bulky Iodotriazolium Tetrafluoroborates as Highly Active Halogen-Bonding-Donor Catalysts
R. Haraguchi, S. Hoshino, M. Sakai, S. Tanazawa, Y. Morita, T. Komatsu, S. Fukuzawa
Chem. Commun. 2018, 54, 10320−10323. Abstract

Transparent Protein Microtubule Motors with Controllable Velocity and Biodegradability
N. Sugai, Y. Nakai, Y. Morita, T. Komatsu
ACS Appl. Nano Mater. 2018, 1, 3080−3085. Abstract
 ・Cover Image 

A Novel Hemoglobin-Based Oxygen Carrier Bound with Albumin Shows Neuroprotection with Possible Antioxidant Effects
M. Gekka, T. Abumiya, T. Komatsu, R. Funaki, K. Kurisu, D. Shimbo, M. Kawabori, T. Osanai, N. Nakayama, K. Kazumata, K. Houkin
Stroke 2018, 49, 1960−1968. Abstract

Core-Shell Protein Clusters Comprising Haemoglobin and Recombinant Feline Serum Albumin as an Artificial O2 Carrier for Cats
K. Yokomaku, M. Akiyama, Y. Morita, K. Kihira, T. Komatsu
J. Mater. Chem. B 2018, 6, 2417−2425. Abstract
 ・Highlighted by Chemistry World
 ・Cover Image  

Self-Propelled Soft Protein Microtubes with a Pt Nanoparticle Interior Surface
S. Kobayakawa, Y. Nakai, M. Akiyama, T. Komatsu
Chem. Eur. J. 2017, 23, 5044−5050. Abstract
 ・Highlighted by Chemistry World
 ・Cover Image 

Structural Insights into a Hemoglobin-Albumin Cluster in Aqueous Medium
R. Shinohara, T. Yamada, B. Schade, C. Böttcher, T. Sato, N. Sugimura, T. Shibue, T. Komatsu
J. Phys. Chem. Lett. 2017, 8, 819−824. Abstract
 ・Featured in Spotlights

Glycoprotein Nanotube Traps Influenza Virus
S. Yuge, M. Akiyama, M. Ishii, H. Namkoong, K. Yagi, Y. Nakai, R. Adachi, T. Komatsu
Chem. Lett. 2017, 46, 95−97. Abstract
 ・Selected as an "Editor's Choice"
 ・Open Access Article

Artificial Blood for Dogs
K. Yamada, K. Yokomaku, M. Kureishi, M. Akiyama, K. Kihira, T. Komatsu
Sci. Rep. 2016, 6, 36782:1−11. Abstract
 ・Open Access Article

Influence of Molecular Strcuture on O2-Binding Properties and Blood Circulation of Hemoglobin-Albumin Clusters
K. Yamada, K. Yokomaku, R. Haruki, K. Taguchi, S. Nagao, T. Maruyama, M. Otagiri, T. Komatsu
PLoS One 2016, 11, e149526:1-15. Abstract
 ・Open Access Article

Highly Sensitive Detection of Organophosphorus Pesticides using 5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin
T. Murakami, Y. Iwamuro, S. Chinaka, N. Takayama, T. Komatsu
Anal. Sci. 2015, 31, 1325−1328. Abstract
 ・Open Access Article

Nanotube Reactor with a Lipase Wall Interior for Enzymatic Ring-Opening Oligomerization of Lactone
Y. Amano, T. Komatsu
Chem. Lett. 2015, 44, 1646−1648. Abstract

Safety Evaluation of Hemoglobin-Albumin Cluster "HemoAct" as a Red Blood Cell Substitute
R. Haruki, T. Kimura, H. Iwasaki, K. Yamada, I. Kamiyama, M. Kohno, K. Taguchi, S. Nagao, T. Maruyama, M. Otagiri, T. Komatsu
Sci. Rep. 2015, 5, 12778:1-9. Abstract
 ・Open Access Article

Core-Shell Clusters of Human Haemoglobin A and Human Serum Albumin: Artificial O2-Carriers Having Various O2-Affinities
T. Kimura, R. Shinohara, C. Böttcher, T. Komatsu
J. Mater. Chem. B 2015, 3, 6157−6164. Abstract
 ・Open Access Article
 ・Cover Image 

Cross-Linked Human Serum Albumin Dimer has the Potential for Use as a Plasma-Retaining Agent for the Fatty Acid-Conjugated Antidiabetic Drugs
K. Taguchi, V. Chuang, K. Yamasaki, Y. Urata, R. Tanaka, M. Anraku, H. Seo, K. Kawai, T. Maruyama, T. Komatsu, M. Otagiri
J. Pharm. Pharmacol. 2015, 67, 255−263. Abstract

Hemoglobin-Albumin Cluster Incorporating a Pt Nanoparticle: Artificial O2 Carrier with Antioxidant Activities
H. Hosaka, R. Haruki, K. Yamada, C. Böttcher, T. Komatsu
PLoS One 2014, 9, e110541:1-9. Abstract
 ・Open Access Article

Haemoglobin Wrapped Covalently by Human Serum Albumin Mutants Containing Mn(III) Protoporphyrin IX: An O2 Complex Stable in H2O2 Solution
Y. Daijima, T. Komatsu
Chem. Commun. 2014, 50, 14716−14719. Abstract
 ・Open Access Article
 ・Cover Image 

Development of Artificial Oxygen Carrier (Red Blood Cell Substitute) =An Ace in the Hole to Overcome the Crisis of "Blood Shortage"= [in Japanese]
T. Komatsu
Chemistry & Chemical Industry「化学と工業」, 2014, 67, 677−679. Contents

An Escherichia coli Trap in Human Serum Albumin Microtubes
S. Yuge, M. Akiyama, T. Komatsu
Chem. Commun. 2014, 50, 9640−9643. Abstract
 ・Open Access Article
 ・Highlighted by Chemistry World
 ・Cover Image 

Fluorescence Dimer and Fiber of meso-Tetrakis{o-(isonicotinoylamino)phenyl}porphyrin Connected by Pd(II) Coordinations
S. Kasuya, Y. Yamazawa, N. Sugimura, T. Shibue, T. Komatsu
Chem. Lett. 2014, 43, 1008−1010. Abstract
 ・Open Access Article

Size-Dependent Dextran Loading in Protein Nanotube with an Interior Wall of Concanavalin A
Y. Shiraishi, M. Akiyama, T. Sato, M. Hattori, T. Komatsu
Polym. Adv. Technol. 2014, 25, 1247−1251. Abstract

Superoxide Dismutase Activity of the Naturally Occurring Human Serum Albumin-Copper Complex without Hydroxyl Radical Formation
R. Kato, M. Akiyama, H. Kawakami, T. Komatsu
Chem. Asian J. 2014, 8, 83−86. Abstract

Gold Nanoparticle Inclusion into Protein Nanotubes as a Layered Wall Component
S. Goto, Y. Amano, M. Akiyama, C. Böttcher, T. Komatsu
Langmuir 2013, 29, 14923−14930. Abstract

Human Serum Albumin Mutants Complexed Mn(III) Protoporphyrin IX as Superoxide Dismutase Mimics
R. Kato, Y. Kobayashi, M. Akiyama, T. Komatsu
Dalton Trans. 2013, 42, 15889−15892. Abstract

Covalent Core-Shell Architecture of Hemoglobin and Human Serum Albumin as an Artificial O2 Carrier
D. Tomita, T. Kimura, H. Hosaka, Y. Daijima, R. Haruki, K. Ludwig, C. Böttcher, T. Komatsu
Biomacromolecules 2013, 14, 1816−1825. Abstract

Structure and Photocatalytic Activity of Iron Oxide Nanotubes Prepared from Ferritin
R. Kato, T. Komatsu
J. Inorg. Organomet. Polym. 2013, 23, 167−171. Abstract

Human Serum Albumin-Based Peroxidase Having an Iron Protoporphyrin IX in Artificial Heme Pocket
K. Watanabe, N. Isihikawa, T. Komatsu
Chem. Asian J. 2012, 7, 2534−2537. Abstract

Protein-Based Nanotubes for Biomedical Applications [Feature Article]
T. Komatsu
Nanoscale 2012, 4, 1910−1918. Abstract
 ・Cover Image 

Human Serum Albumin Nanotubes with Esterase Activity
T. Komatsu, T. Sato, C. Böttcher
Chem. Asian J. 2012, 7, 201−206. Abstract

Protein Nanotube Arrays Immobilized on Solid Substrates: Molecular Trap in Aqueous Medium
R. Kato, T. Komatsu
Chem. Lett. 2011, 40, 1338−1339. Abstract

Virus Trap in Human Serum Albumin Nanotube
T. Komatsu, X. Qu, H. Ihara, M. Fujihara, H. Azuma, H. Ikeda
J. Am. Chem. Soc. 2011, 133, 3246−3248. Abstract
 ・Highlighted by Chemistry World

Protein Nanotubes Bearing a Magnetite Surface Exterior
T. Komatsu, N. Kobayashi
Polym. Adv. Technol. (Prof. E. Tsuchida Special Issue) 2011, 22, 1315−1318. Abstract

Protein Nanotubes with an Enzyme Interior Surface
T. Komatsu, H. Terada, N. Kobayashi
Chem. Eur. J. 2011, 17, 1849−1854. Abstract

Superior Plasma Retension of a Cross-Linked Human Serum Albumin Dimer in Nephrotic Rats as a New Type of Plasma Expander
K. Taguchi, Y. Urata, M. Anraku, H. Watanabe, K. Kawai, T. Komatsu, E. Tsuchida, T. Maruyama, M. Otagiri
Drug Metab. Dispos. 2010, 38, 2124−2129. Abstract

Molecular Insight of Intrinsic Heme Distortion to the Ligand Binding in Hemoprotein
S. Neya, M. Suzuki, T. Hoshino, H. Ode, K. Imai, T. Komatsu, A. Ikezaki, M. Nakamura, Y. Furutani, H. Kandori
Biochemistry 2010, 49, 5642−5650. Abstract

Solid Nanotubes Comprising α-Fe2O3 Nanoparticles Prepared from Ferritin Protein
X. Qu, N. Kobayashi, T. Komatsu
ACS Nano 2010, 4, 1732−1738. Abstract

Molecular Capture in Protein Nanotubes
X. Qu, T. Komatsu
ACS Nano 2010, 4, 563−573. Abstract
 ・Highlighted by Nanowerk


2000−2009 articles

●The articles before 2000 are omitted.


Book Chapters

Development of Artificial Oxygen Carriers as Red Blood Cell Substitutes. [in Japanese]
Y. Morita, T. Komatsu
Frontier Functional Macromolecule-Metal Complexes, Ed. H. Nishihara, K. Yamamoto, p. 300−323, Sankyo Shuppan (Tokyo, 2020) ContentNEW

Hemoglobin-Albumin Clusters as a Red Blood Cell Substitute
T. Komatsu
Albumin in Medicine. Pathological and Clinical Applications, Ed. M. Otagiri, V. T. Giam Chuang, p. 165−178 (Chapter 9), Springer (Tokyo, 2016) Abstract

Synthesis and Application of Protein Nanotubes. [in Japanese]
T. Komatsu, M. Akiyama
Design of Supramolecular Structures and Development for the Application, Ed. A. Harada, p. 64−71, CMC (Osaka, 2014)

Albumin-Heme Oxygen Carriers
T. Komatsu
Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics, Ed. H. W. Kim, A. G. Greenburg, p. 339−348 (Chapter 18), Springer-Verlag (Berlin Heidelberg, 2013) Abstract

Albumin-Heme as an O2-Carrying Plasma Protein
T. Komatsu
Human Serum Albumin −New Insights on its Structural Dynamics, Functional Impacts and Pharmaceutical Applications, Ed. M. Otagiri, p. 332−345 (Chapter 17), Sojo Univ. Pub. (Kumamoto, 2013)

Synthesis of Protein Nanotubes using Layer-by-Layer Assembly Technique [in Japanese]
T. Komatsu
Organic, Inorganic, and Metallic Nanotubular Materials -Recent Technologies and Applications of Various Nanotubes Excluding Carbon Nanotubes-, Eds. T. Shimidzu, T. Kijima, p. 82−88, Frontier (Tokyo, 2008)

Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier
T. Komatsu, Y. Huang, H. Yamamoto, H. Horinouchi, K. Kobayashi, E. Tsuchida
Blood Substitutes, Ed. R. Winslow, p. 532−539 (Chapter 46), Elsevier (London, 2006)

Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme
T. Komatsu, E. Tsuchida
Artificial Oxygen Carrier. Its Front Line, Eds. K. Kobayashi, E. Tsuchida, H. Horinouchi, p. 193−204, Springer-Verlag (Tokyo, 2005)

Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes
K. Kobayashi, H. Horinouchi, M. Watanabe, Y. Izumi, Y. Teramura, A. Nakagawa, Y. Huang, K. Sou, H. Sakai, T. Komatsu, S. Takeoka, E. Tsuchida
Artificial Oxygen Carrier. Its Front Line, Eds. K. Kobayashi, E. Tsuchida, H. Horinouchi, p. 1−21, Springer-Verlag (Tokyo, 2005)

Synthesis and Oxygen Transport of Hydrpophobic Porphyrin Assemblies [in Japanese]
H. Nishide, T. Komatsu, E. Tsuchida
New Development of Softmaterials, Ed. T. Nishi, p. 16−26, CMC (Tokyo, 2004)


●The articles before 2000 are omitted.